If one watched enough of the show, the abilities of many of its characters and powers would result in op levels rivals the best of the comic and manga worlds.
Professor Farnsworth – He is an unparalleled genius in fields of science and inventions who has created contraptions capable of destroying entire worlds, manipulating time, reality, or genetics. As a time master, he can undo his mistakes or rewrite the history of the universe. His collection of weaponry reveals an arsenal able to destroy entire planets. He has a pet griffin or similar creature that quite strong and can fly. Farnsworth can create a means to travel to alternative universes.
Bender Rodriguez – By accumulation of powers from the entirety of the series, Bender can self replicate enough to overwhelm worlds. He’s already by default stronger than many organic life forms. Like inspector gadget, he has compartments to store or release many a variety of tools and gear. His fingers have Batman/Bionic man like utilities. In other aspects, he has even become a world ruler and even a god to an entire alien species. Bender can be extremely fast especially if boosted by external means like lightning. He’s been known to speak to animals, build or craft, or steal with greater skill than a pickpocket. Lastly, he can overclock his cpu and boost his intellect and abilities to near Nero of Matrix or Lawnmower man levels and reach near divinity since in this state he can create and recombine matter.
Turanga Leela – She’s acquired super human powers like speed, strength, and flight. Her personal combat skill is on par with many comic characters seeing as she’s taken on multiple opponents or large adversaries easily. Her increased physique came twice over in two episodes, so if accumulated she would theoretically be a boosted superhero even. Leela is extremely intelligent and a capable space craft pilot which could make her comparable to Buck Rogers, Star Lord, or Skywalker. She wears a device similar to a pipboy as seen in Fallout with at least some similar functions.
Phillip J. Fry – In his best most ability increased episodes, he can become a virtual genius in a virtually immortal body capable of self healing from what would be fatal injuries to most humans. This particular set of skills makes him super fit, healthy, and stronger than average. Like Leela, he also acquired super human powers with increased speed, strength, and flight. He acquired the telepathy skill in the movie “Wild Green Yonder”. Phillip is the only life form in the universe capable of defeating one of the universe’s most ancient and powerful enemies. In other episodes, he used contraptions to move planets. Phillip developed connections to other creatures most humans wouldn’t even try such as having a powerful pet vampire bat chameleon like mix creature. If he drinks coffee, Phillip has the ability to move fast enough to essentially make time stop or appear so to him.
Amy Wong – Most of the time, Amy appears to be an airhead with a penchant for getting around, but she’s also a genius herself as an understudy of the professor. A y demonstrated the ability to stop the rotation of earth or change direction of its rotation. Her wealth gives her access to nearly unlimited beauty products, vehicles, fashionable clothes, or travel. She has a potent charm and open mind.
Dr. John Zoidberg – Zoidberg as an alien, already has a few built in natural features beyond the average human. He can release ink to incapacitate would be enemies or cut better than cut specific built robots. Though absent minded and goofy about many subjects, he’s actually a genius in xenobiology and xenomicrobiology. Physically, he’s generally stronger than the average human. He’s a skilled negotiator who can convince entire worlds into war if he’s cornered as those skills get boosted when it matters. In some episodes, he’s more than capable of martial combat especially with nunchucks like weapons and can go into a type of physical boosted berserker mode when angered almost like hulk but not quite the same power boost level.
Dr. Ogden Wornstrom – Ogden, like Farnsworth, is a genius who can create powerful ray weapons
Al Gore’s head – Al Gore in futurama, among other things, runs a secret defense organization akin to Nick Fury. Al is smart with many connections and access to information not available even to most if not all world leaders.
Richard Nixon’s Head – For some, he was already a bit of a supervillain or maybe just crafty enough to avoid getting in trouble for something worse? In the series, he’s usually the president of the world with enormous powers. At times, he’s morphed his head onto a powerful robot body, which alone could have trounced robocop and given Rom a hard time.
Calculon – Calculon is a member of a secret powerful organization. As a robot, he’s been shown to actually outmatch Bender before either uses exceptional powers or boosts of any kind. He’s dramatic, self centered, narcissistic, and selfish mostly though can curb his usual traits when desired. Calculon is a capable shapeshifter monster who can become a werecar though he in theory may not have control, though that can’t be certain due to lack of screen time as his alter ego.
Hermès Conrad – Hermès would be virtually superhuman without any modifications or special episodes because he’s a walking calculator and bureaucracy sorting machine. He’s probably the most limber member of the show given his near supernatural limbo skills. In one episode he became a bionic cyborg then an android to become even more efficient. Though, it wasn’t his tools, Hermès has held the power and fate of the universe in his hands at least once, which is one more then most superheroes or supervillains.
I may well be missing a few but this should be most if not all of the regulars. However, I will update it as a work in progress.
epic philosophy 